TAM Receptor

The TAM receptor family consists of three receptor tyrosine kinases: TYRO3, AXL, and MER. These receptors are essential for regulating immune response, cell survival, migration, and clearance of apoptotic cells. TAM receptors interact with Vitamin K-dependent proteins GAS6 and PROS1 as ligands, facilitating the removal of apoptotic debris and maintaining immune system homeostasis. Dysregulation of TAM signaling is linked to a variety of diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. In cancer, particularly, AXL is noted for promoting tumor growth, survival, resistance to therapy, and metastasis. Consequently, TAM receptors are attractive targets for therapeutic intervention, aiming to modulate immune responses and inhibit cancer progression.