PKA

Protein Kinase A (PKA) is a key enzyme in cellular signaling that regulates various physiological processes by phosphorylating serine and threonine residues on target proteins. It plays a central role in metabolic regulation, gene expression, memory formation, and cell proliferation. PKA is activated by cyclic AMP (cAMP), a second messenger produced in response to hormonal signals like adrenaline and glucagon. The activation of PKA leads to the phosphorylation and modulation of the activity of numerous substrates within the cell, influencing diverse cellular pathways. Dysregulation of PKA activity is linked to several diseases, including certain types of cancer and cardiovascular disorders, making it a significant target for therapeutic intervention.