Wnt

The Wnt signaling pathway is a complex network of proteins known for its roles in regulating embryonic development and maintaining adult tissue homeostasis. It is primarily involved in controlling cell fate, proliferation, migration, and polarity. Wnt proteins bind to Frizzled receptors and co-receptors such as LRP5/6, initiating a signaling cascade that either stabilizes β-catenin in the canonical pathway or activates non-canonical pathways influencing cell behavior through calcium flux and other mechanisms. Dysregulation of Wnt signaling is linked to numerous diseases, including cancer, osteoporosis, and degenerative diseases. Due to its critical role in cell growth and differentiation, the Wnt pathway is a key target for therapeutic intervention in these conditions.