(±)-Anatoxin A fumarate

• CAT Number: R017680
• CAS Number: 1219922-30-1
• Molecular Formula: C14H19NO5
• Molecular Weight: 281.30
• Purity: ≥95%
• Synonyms: 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone;(E)-but-2-enedioic acid
• InChI: InChI=1S/C10H15NO.C4H4O4/c1-7(12)9-4-2-3-8-5-6-10(9)11-8;5-3(6)1-2-4(7)8/h4,8,10-11H,2-3,5-6H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: ZJSIFVODFDHYJU-WLHGVMLRSA-N
• SMILES: CC(=O)C1=CCCC2CCC1N2.C(=CC(=O)O)C(=O)O

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

Reference

[1]. P Thomas, et al. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem. 1993 Jun;60(6):2308-11.
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