For research use only. Not for therapeutic Use.
UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).
| Catalog Number | R041642 |
| CAS Number | 1093757-42-6 |
| Synonyms | CID-888026; |
| Molecular Formula | C14H15Cl2NO3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at RT |
| InChI | InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1 |
| InChIKey | VSMUYYFJVFSVCA-NWDGAFQWSA-N |
| SMILES | O=C([C@H]1[C@@H](C(NC2=CC(Cl)=CC(Cl)=C2)=O)CCCC1)O |
| Reference | </br>1: Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL,</br> Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB,</br> Ayala JE, Williams R, Lindsley CW, Conn PJ. Discovery, characterization, and</br> antiparkinsonian effect of novel positive allosteric modulators of metabotropic</br> glutamate receptor 4. Mol Pharmacol. 2008 Nov;74(5):1345-58. doi:</br> 10.1124/mol.108.049551. PubMed PMID: 18664603; PubMed Central PMCID: PMC2574552.</br> |
