(±)-Verapamil-d3 (hydrochloride)

• CAT Number: R065795
• Molecular Formula: C27H35D3N2O4 • HCl
• Molecular Weight: 494.1
• Purity: ≥95%
• Synonyms: 5-((3,4-dimethoxyphenethyl)(methyl-d3)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile, monohydrochloride
• Storage: -20°C
• IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-(trideuteriomethyl)amino]-2-propan-2-ylpentanenitrile;hydrochloride
• InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/i3D3
• InChIKey: DOQPXTMNIUCOSY-FJCVKDQNSA-N
• SMILES: [2H]C([2H])([2H])N(CCCC(C#N)(C1=CC(=C(C=C1)OC)OC)C(C)C)CCC2=CC(=C(C=C2)OC)OC.Cl

(±)-Verapamil-d3 (hydrochloride) is a deuterated analog of verapamil, a calcium channel blocker used primarily in the treatment of hypertension and angina. The deuteration of verapamil enhances its utility in pharmacokinetic and metabolic studies by improving the precision of tracking and quantification in mass spectrometry. This compound, used mainly in research, helps in studying drug metabolism, bioavailability, and pharmacodynamics by providing clearer insights into the drug’s behavior in biological systems. Its use is particularly relevant in pharmaceutical research to optimize drug development and efficacy.