For research use only. Not for therapeutic Use.
β-Boswellic acid is a pentacyclic triterpene originally isolated from <em>Boswellia</em> that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC<sub>50</sub> value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. <span class=/itemid/>11672</span>). It inhibits cell proliferation in HL-60 cells with IC<sub>50</sub> values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVEC) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC<sub>50</sub> = 8 µM).
| Catalog Number | R002091 |
| CAS Number | 631-69-6 |
| Synonyms | (3α,4β)-3-Hydroxyurs-12-en-23-oic Acid; |
| Molecular Formula | C30H48O3 |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | NBGQZFQREPIKMG-KPQZNPKPSA-N |
