For research use only, not for therapeutic use.
ζ-Stat (Cat No.:I014807), also known as NSC37044, is a specific and atypical inhibitor of PKC-ζ (protein kinase C-zeta). It has an IC50 of 5 μM against PKC-ζ. ζ-Stat has demonstrated the ability to reduce proliferation and induce apoptosis in melanoma cell lines, showcasing potential antitumor activity in vitro. It shows limited inhibition on PKC-ι but exhibits significant inhibition on PKC-ζ. Treatment with ζ-Stat results in decreased cell proliferation in SK-MEL-2 and MeWo cells with increasing concentrations. Combining ζ-Stat with 5-FU has shown a synergistic effect in reducing the viability of LoVo CRC cells. ζ-Stat treatment also leads to a reduction in phosphorylated and total PKC-ζ, Bcl-2, and PARP levels, while increasing Caspase-3 and cleaved-PARP levels in melanoma cells
| Catalog Number | I014807 |
| CAS Number | 3316-02-7 |
| Molecular Formula | C₁₀H₈O₁₀S₃ |
| Purity | ≥95% |
| IUPAC Name | 8-hydroxynaphthalene-1,3,6-trisulfonic acid |
| InChI | InChI=1S/C10H8O10S3/c11-8-3-6(21(12,13)14)1-5-2-7(22(15,16)17)4-9(10(5)8)23(18,19)20/h1-4,11H,(H,12,13,14)(H,15,16,17)(H,18,19,20) |
| InChIKey | KMXMLAGYNHELHA-UHFFFAOYSA-N |
| SMILES | C1=C2C=C(C=C(C2=C(C=C1S(=O)(=O)O)O)S(=O)(=O)O)S(=O)(=O)O |
| Reference | [1]. Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.<br>[2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665. |
