(±)-β-Hydroxybutyrate

• CAT Number: R064686
• CAS Number: 300-85-6
• Molecular Formula: C4H8O3
• Molecular Weight: 104.105
• Purity: ≥95%
• Synonyms: 3-Hydroxybutyric Acid;NSC 3806
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: 3-hydroxybutanoic acid
• InChI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)
• InChIKey: WHBMMWSBFZVSSR-UHFFFAOYSA-N
• SMILES: CC(CC(=O)O)O

(±)-β-Hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), increasing acetylation of histones in a dose-dependent manner. It does not increase acetylation of α-tubulin, indicating that it does not inhibit the class IIb HDAC6. Fasting or caloric restriction, two conditions associated with increased βOHB abundance, increases global histone acetylation in mouse tissues.

Reference

1.Shimazu, T.,Hirschey, M.D.,Newman, J., et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211-214 (2013).