For research use only. Not for therapeutic Use.
<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">(±)12-<wbr />HETE(CAS 71030-37-0) is one of the six monohydroxy fatty acids produced by the non-<wbr />enzymatic oxidation of arachidonic acid. The biological activity of (±)12-<wbr />HETE is similar to that of its constituent enantiomers. It aggregates neutrophils with an EC<sub>50</sub> value of 40 nM.</span></span></span>
| Catalog Number | R067261 |
| CAS Number | 71030-37-0 |
| Synonyms | (±)12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid |
| Molecular Formula | C20H32O3 |
| Purity | ≥95% |
| Target | Apoptosis |
| Storage | -20°C |
| IUPAC Name | (5Z,8Z,10E,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid |
| InChI | InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+ |
| InChIKey | ZNHVWPKMFKADKW-VXBMJZGYSA-N |
| SMILES | CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)O |
| Reference | 1.O/'Flaherty, J.T.,Thomas, M.J.,Lees, C.J., et al. Neutrophil-aggregating activity of monohydroxyeicosatetraenoic acids. American Journal of Pathology 104, 55-62 (1981). |
