For research use only. Not for therapeutic Use.
(±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].
(±)-2-Propyl-4-pentenoic acid (1 mM; 26 h) induces approximately 50% of dysmorphogenic mouse embryos[2].
| Catalog Number | R007497 |
| CAS Number | 1575-72-0 |
| Synonyms | 2-propylpent-4-enoic acid |
| Molecular Formula | C8H14O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H14O2/c1-3-5-7(6-4-2)8(9)10/h3,7H,1,4-6H2,2H3,(H,9,10) |
| InChIKey | UMYDNZXEHYSVFY-UHFFFAOYSA-N |
| SMILES | CCCC(CC=C)C(=O)O |
| Reference | [1]. W Tang, et, al. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab Dispos. 1997 Feb;25(2):219-27. [2]. Gofflot F, et, al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol Teratol. Jul-Aug 1995;17(4):425-35. |
