For research use only. Not for therapeutic Use.
(±)-cis-Sertraline-d3 hydrochloride (CAS: 1217741-83-7), a premium pharmaceutical research compound designed for advanced psychopharmacological studies. As a deuterated analog of Sertraline, it offers enhanced stability and improved pharmacokinetic properties. (±)-cis-Sertraline-d3 hydrochloride is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel antidepressant therapies. Trusted by leading laboratories, (±)-cis-Sertraline-d3 hydrochloride is your go-to solution for cutting-edge mental health research. Unlock new possibilities in depression treatment with (±)-cis-Sertraline-d3 hydrochloride, where innovation meets reliability.
| Catalog Number | S000254 |
| CAS Number | 1217741-83-7 |
| Molecular Formula | C17H15D3Cl3N |
| Purity | ≥95% |
| Target | Serotonin Transporter |
| IUPAC Name | (1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride |
| InChI | InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1/i1D3; |
| InChIKey | BLFQGGGGFNSJKA-FEGLBNOFSA-N |
| SMILES | [2H]C([2H])([2H])N[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24. [3]. Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7. [4]. Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1. [5]. Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24. |
