(±)-E-Homocamptothecin

For research use only. Not for therapeutic Use.

  • CAT Number: I026757
  • CAS Number: 186668-40-6
  • Molecular Formula: C21H18N2O4
  • Molecular Weight: 362.38
  • Purity: ≥95%
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A potent topoisomerase I (Topo 1) inhibitor; Homocamptothecin (hCPT) is an E-ring modified analogue of camptothecin (CPT), with enhanced stability and potent Topo-1 mediated activity; apoptosis agent


Catalog Number I026757
CAS Number 186668-40-6
Molecular Formula C21H18N2O4
Purity ≥95%
IUPAC Name 20-ethyl-20-hydroxy-17-oxa-3,13-diazapentacyclo[11.9.0.02,11.04,9.015,21]docosa-1(22),2,4,6,8,10,15(21)-heptaene-14,18-dione
InChI InChI=1S/C21H18N2O4/c1-2-21(26)9-18(24)27-11-14-15(21)8-17-19-13(10-23(17)20(14)25)7-12-5-3-4-6-16(12)22-19/h3-8,26H,2,9-11H2,1H3
SMILES CCC1(CC(=O)OCC2=C1C=C3C4=NC5=CC=CC=C5C=C4CN3C2=O)O
Reference

L Lesueur-Ginot et al. Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties. Cancer Res. 1999, 59(12), 2939-2943.

 

O Lavergne et al. Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues. J. Med. Chem. 1998, 41(27), 5410–5419.

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