For research use only. Not for therapeutic Use.
(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].
mGluR1a拮抗剂
| Catalog Number | I031235 |
| CAS Number | 198419-90-8 |
| Synonyms | 4-[amino(carboxy)methyl]-3-methylbenzoic acid |
| Molecular Formula | C10H11NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15) |
| InChIKey | SGIKDIUCJAUSRD-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N |
| Reference | [1]. Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780. [2]. V Bruno, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a |
