For research use only. Not for therapeutic Use.
(±)-trans-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50 values of 3.1 and 28.5 µM, respectively) and an activator of TRPML2 (EC50 value of 3.3 µM. KEYWORDS: (±)-trans-ML-SI3 | Supplier | TRPML1/3 inhibitor;TRPML2 activator | MLSI3 | ML SI3 | rac-trans-ML-SI3 | CAS [2108567-79-7] | Non Selective (Cations) | TRPML | Activator | Inhibitor | Ion Channels
| Catalog Number | I047725 |
| CAS Number | 2108567-79-7 |
| Molecular Formula | C23H31N3O3S |
| Purity | ≥95% |
| IUPAC Name | N-[(1R,2R)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide |
| InChI | InChI=1S/C23H31N3O3S/c1-29-23-14-8-7-13-22(23)26-17-15-25(16-18-26)21-12-6-5-11-20(21)24-30(27,28)19-9-3-2-4-10-19/h2-4,7-10,13-14,20-21,24H,5-6,11-12,15-18H2,1H3/t20-,21-/m1/s1 |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)[C@@H]3CCCC[C@H]3NS(=O)(=O)C4=CC=CC=C4 |
| Reference | C Leser et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;0(0):112966.W Wang et al. Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1373-81. |
