α-Conotoxin GI

• CAT Number: P000397
• CAS Number: 76862-65-2
• Molecular Formula: C55H80N20O18S4
• Molecular Weight: 1437.61
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1NC(=O)C2CCCN2C(=O)C(CC(N)=O)NC(=O)C3CSSCC(NC(=O)C(CO)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CC5=CN=C[NH]5)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(CSSCC(NC(=O)C(N)CCC(O)=O)C(=O)N3)NC1=O)C(N)=O

α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ.

Reference

[1] Knuhtsen A, et al. Chem. Sci., 2019, 10, 1671-1676.