α-Ergocryptine

• CAT Number: R050248
• CAS Number: 511-09-1
• Molecular Formula: C32H41N5O5
• Molecular Weight: 575.71
• Purity: 98%
• Synonyms: (5’α)-12’-Hydroxy-2’-(1-methylethyl)-5’-(2-methylpropyl)ergotaman-3’,6’,18-trione; ?Ergocryptine; Ergokryptine; NSC 169479; NSC 407319; α-Ergocryptine; α-Ergokryptine
• Appearance: Pale Yellow Solid
• Storage: Store at -20°C
• IUPAC Name: (6aR,9R)-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
• InChI: InChI=1S/C32H41N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,13,15,17-18,20,24-26,33,41H,7,10-12,14,16H2,1-5H3,(H,34,38)/t20-,24-,25+,26+,31-,32+/m1/s1
• InChIKey: YDOTUXAWKBPQJW-NSLWYYNWSA-N
• SMILES: CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O

α-Ergocryptine is an ergot alkaloid derived from the fungus Claviceps purpurea, commonly found in grains like rye. It belongs to a class of compounds known for their bioactive properties, particularly their effects on the central nervous system and the endocrine system. α-Ergocryptine acts as a dopamine receptor agonist, influencing prolactin secretion and making it useful in the treatment of conditions like hyperprolactinemia. It has also been explored for its potential to treat Parkinson’s disease and other disorders associated with dopamine regulation. Due to its vasoconstrictive properties, it is closely monitored in therapeutic applications to avoid adverse effects.