For research use only. Not for therapeutic Use.
α-Factor Mating Pheromone, yeast (Cat.No:I020211) is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor.<br>α-Factor Mating Pheromone, yeast is synthesized constitutively by MATα cells and acting on MATa cells[1]. α-Factor Mating Pheromone, yeast inhibits the division cycle of yeast a cells, and competes for binding of 35S-α-factor to haploid a cells, with Kd of 0.3 μM, and this binding is related to five temperature-sensitive ste2 mutants, and is thermolabile. However, α-Factor Mating Pheromone, yeast binding activity of other temperature-sensitive mutants (ste4, ste5, ste7, ste11, and ste12) shows no thermolability[2].
| Catalog Number | I020211 |
| CAS Number | 59401-28-4 |
| Molecular Formula | C₈₂H₁₁₄N₂₀O₁₇S |
| Purity | ≥95% |
| Reference | [1]. Naider F, et al. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides. 2004 Sep;25(9):1441-63.<br>[2]. Jenness DD, et al. Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor. Cell. 1983 Dec;35(2 Pt 1):521-9. |
