α-KGA

• CAT Number: I038798
• CAS Number: 22202-68-2
• Molecular Formula: C5H6NaO5
• Molecular Weight: 169.09
• Purity: 98%
• Synonyms: α-KGA; αKGA; α KGA; 2-Oxoglutaric Acid; 2 Oxoglutaric Acid; α-Ketoglutaric Acid; α Ketoglutaric Acid; α-Ketoglutaric Acid sodium salt; α Ketoglutaric Acid sodium salt
• Target: Tyrosinase
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: sodium;5-hydroxy-2,5-dioxopentanoate
• InChI: InChI=1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10)
• InChIKey: GPRYXSKURSLOCH-UHFFFAOYSA-N
• SMILES: C(CC(=O)O)C(=O)C(=O)[O-].[Na+]

α-Ketoglutaric Acid(CAT: I038798) is a vital intermediate in the citric acid (Krebs) cycle, formed via oxidative decarboxylation of isocitrate, glutamate deamination, or transamination. It is decarboxylated to succinyl-CoA by α-ketoglutarate dehydrogenase, a rate-limiting step in energy production. Beyond its metabolic role, it is a precursor for glutamine and glutamate, essential for protein synthesis and immune cell energy. α-Ketoglutaric Acid also functions as an antioxidant, influencing immune homeostasis, aging, and bone development. Its versatility makes it crucial in metabolic and cellular research, supporting studies on energy production, oxidative stress, and therapeutic interventions for age-related and metabolic disorders.