α-Lipoic acid-NHS

• CAT Number: I016489
• CAS Number: 40846-94-4
• Molecular Formula: C₁₂H₁₇NO₄S₂
• Molecular Weight: 303.41
• Purity: ≥95%
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 5-(dithiolan-3-yl)pentanoate
• InChI: InChI=1S/C12H17NO4S2/c14-10-5-6-11(15)13(10)17-12(16)4-2-1-3-9-7-8-18-19-9/h9H,1-8H2
• InChIKey: WBCUIGFYTHUQHZ-UHFFFAOYSA-N
• SMILES: C1CSSC1CCCCC(=O)ON2C(=O)CCC2=O

α-Lipoic acid-NHS(CAT: I016489) is a compound that combines α-lipoic acid with N-hydroxysuccinimide (NHS) functionality. NHS esters are widely used in bioconjugation chemistry to covalently link molecules to primary amines, such as amino acids or proteins. By incorporating the NHS group, α-lipoic acid-NHS can react with primary amines through nucleophilic attack, forming stable amide bonds. This enables the conjugation of α-lipoic acid to other molecules or surfaces, allowing for applications in drug delivery, targeted therapy, and bioconjugate chemistry.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562