α-Lipoic acid-NHS

• CAT Number: I016489
• CAS Number: 40846-94-4
• Molecular Formula: C₁₂H₁₇NO₄S₂
• Molecular Weight: 303.4
• Purity: ≥95%

α-Lipoic acid-NHS(CAT: I016489) is a compound that combines α-lipoic acid with N-hydroxysuccinimide (NHS) functionality. NHS esters are widely used in bioconjugation chemistry to covalently link molecules to primary amines, such as amino acids or proteins. By incorporating the NHS group, α-lipoic acid-NHS can react with primary amines through nucleophilic attack, forming stable amide bonds. This enables the conjugation of α-lipoic acid to other molecules or surfaces, allowing for applications in drug delivery, targeted therapy, and bioconjugate chemistry.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562