α-NETA

• CAT Number: R064980
• CAS Number: 31059-54-8
• Molecular Formula: C16H20NO • I
• Molecular Weight: 369.2
• Purity: ≥95%
• Synonyms: N,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide
• Storage: -20°C
• InChI: InChI=1S/C16H20NO.HI/c1-17(2,3)11-10-16(18)15-9-8-13-6-4-5-7-14(13)12-15;/h4-9,12H,10-11H2,1-3H3;1H/q+1;/p-1
• InChIKey: LIFHUGCXEAQKRZ-UHFFFAOYSA-M
• SMILES: O=C(CC[N+](C)(C)C)C1=CC2=CC=CC=C2C=C1.[I-]

Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-<wbr></wbr>CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-<wbr></wbr>NETA is a stable, non-<wbr></wbr>competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-<wbr></wbr>NETA is commonly used in cells in culture.

Reference

1.Shen, X.M.,Crawford, T.O.,Brengman, J., et al. Functional consequences and structural interpretation of mutations of human choline acetyltransferase. Human Mutation 32(11), 1259-1267 (2011).