For research use only. Not for therapeutic Use.
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors[1].
α2β1 Integrin Ligand Peptide (DGEA) TFA (0.015-2.0 mM) inhibits SA11, RRV, and Wa infection in a dose-dependent manner and had no effect on CRW-8 infectivity[1].?
α2β1 Integrin Ligand PeptideTFA induces tyrosine kinase-dependent calcium mobilization in osteoblasts and fibroblasts at concentrations of ≥0.5 mM[1].?
α2β1 Integrin Ligand Peptide TFA loses its ability to inhibit SA11 binding at 1.0 mM[1].
| Catalog Number | I046025 |
| Synonyms | (4S)-4-[[2-[[(2S)-2-amino-3-carboxypropanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxyethyl]amino]-5-oxopentanoic acid;2,2,2-trifluoroacetic acid |
| Molecular Formula | C16H23F3N4O11 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H22N4O9.C2HF3O2/c1-6(14(26)27)17-13(25)8(2-3-10(20)21)18-9(19)5-16-12(24)7(15)4-11(22)23;3-2(4,5)1(6)7/h6-8H,2-5,15H2,1H3,(H,16,24)(H,17,25)(H,18,19)(H,20,21)(H,22,23)(H,26,27);(H,6,7)/t6-,7-,8-;/m0./s1 |
| InChIKey | UIPQURHVPOBFKI-WQYNNSOESA-N |
| SMILES | CC(C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC(=O)O)N.C(=O)(C(F)(F)F)O |
| Reference | [1]. Graham KL, et al. Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequences. J Virol. 2004 Nov;78(21):11786-97. |
