β-Amyloid (1-40) (rat)

• CAT Number: M127834
• CAS Number: 144409-98-3
• Molecular Formula: C190H291N51O57S
• Molecular Weight: 4233.76
• Purity: ≥95%

β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer’s disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer’s disease[1][2].
β-Amyloid (1-40) (rat) (1 μM; 1 h) increases 45Ca2+ influx and elevates Ca2+ in cortical synaptosomes[1].
β-Amyloid (1-40) (rat) (3 nM) induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield and induces apoptosis[2].
β-Amyloid (1-40) (rat) (1.7 mg; ICV, for 7 d; swiss and C57BL/6 mice) induces the learning and memory deficits in mice[3].

Reference

[1]. MacManus A, et, al. Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem
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[2]. Miguel-Hidalgo JJ, et, al. Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. Acta Neuropathol. 1998 May;95(5):455-65.
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[3]. Prediger RD, et, al. Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav Brain Res. 2007 Feb 2
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