γ-Secretase modulator 4

• CAT Number: I046204
• CAS Number: 1420200-82-3
• Molecular Formula: C23H19FN4O2
• Molecular Weight: 402.42
• Purity: ≥95%
• Synonyms: 2-[(8S)-8-(3-fluoro-2-methylphenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1H-indole-5-carbonitrile
• InChI: InChI=1S/C23H19FN4O2/c1-13-15(4-3-5-17(13)24)22-23-27-20(12-28(23)8-9-30-22)19-10-16-18(26-19)7-6-14(11-25)21(16)29-2/h3-7,10,12,22,26H,8-9H2,1-2H3/t22-/m0/s1
• InChIKey: UBJJQXXWGRHIDV-QFIPXVFZSA-N
• SMILES: CC1=C(C=CC=C1F)C2C3=NC(=CN3CCO2)C4=CC5=C(N4)C=CC(=C5OC)C#N

γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively[1].

Reference

[1]. Bischoff FP, et al. Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1737-1745.
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