Δ4-Dafachronic Acid

• CAT Number: I011696
• CAS Number: 23017-97-2
• Molecular Formula: C27H42O3
• Molecular Weight: 414.63
• Purity: ≥95%
• Synonyms: 3-oxo-cholest-4-en-26-oic acid
• Target: Nuclear Receptors
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (6R)-6-[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
• InChI: InChI=1S/C27H42O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h16-18,21-24H,5-15H2,1-4H3,(H,29,30)/t17-,18?,21+,22-,23+,24+,26+,27-/m1/s1
• InChIKey: PSXQJZDFWDKBIP-NNWQCNCGSA-N
• SMILES: CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Δ4-Dafachronic acid(CAT: I011696) is a steroid hormone that regulates the developmental timing of dauer formation in nematodes. It is a member of the dafachronic acid family of hormones, which are synthesized from cholesterol in response to environmental and nutritional cues. In the nematode Caenorhabditis elegans, Δ4-dafachronic acid acts as an endocrine signal that inhibits the formation of the dauer larva, a developmentally arrested and stress-resistant stage that is triggered by adverse environmental conditions. Δ4-Dafachronic acid exerts its effects by binding to the nuclear hormone receptor DAF-12, which in turn regulates the expression of genes involved in developmental timing and metabolism.