(−)-L-threo-PDMP (hydrochloride)

• CAT Number: R060973
• CAS Number: 161491-04-9
• Molecular Formula: C23H38N2O3 • HCl
• Molecular Weight: 427
• Purity: 98%
• Appearance: Solid
• Related CAS: 109836-81-9
• Analysis method: TLC
• IUPAC Name: N-[(1S,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride
• InChI: InChI=1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m0./s1
• InChIKey: HVJHJOYQTSEKPK-IUQUCOCYSA-N
• SMILES: CCCCCCCCCC(N[C@H]([C@@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl

(−)-L-threo-PDMP (hydrochloride) is a synthetic glycolipid analog that acts as an inhibitor of glucosylceramide synthase, an enzyme crucial for glycosphingolipid biosynthesis. By blocking the production of glucosylceramide, it disrupts the formation of complex glycosphingolipids, making it a valuable research tool for studying sphingolipid metabolism and related pathways. This compound has been used in studies focused on cancer, neurodegenerative diseases, and metabolic disorders, as glycosphingolipids play significant roles in cell signaling, apoptosis, and membrane structure. Its hydrochloride salt form enhances its solubility and stability, making it suitable for both in vitro and in vivo experimental applications.