1-(3,3-Dimethyl-1,2-dioxopentyl)-L-proline 3-(3-pyridinyl)propyl Ester

• CAT Number: R041687
• CAS Number: 186452-09-5
• Molecular Formula: C20H28N2O4
• Molecular Weight: 360.45
• Purity: ≥95%
• Synonyms: GPI 1046
• Storage: 2-8°C
• IUPAC Name: 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
• InChI: InChI=1S/C20H28N2O4/c1-4-20(2,3)17(23)18(24)22-12-6-10-16(22)19(25)26-13-7-9-15-8-5-11-21-14-15/h5,8,11,14,16H,4,6-7,9-10,12-13H2,1-3H3/t16-/m0/s1
• InChIKey: OQAHHWOPVDDWHD-INIZCTEOSA-N
• SMILES: CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2

GPI-1046（Cat No.:R041687） is an immunophilin ligand known for its ability to reduce ethanol intake by upregulating the expression of glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens (NAc) core. It does not possess antibiotic properties. Being an analog of FK506, GPI-1046 exhibits neuroprotective effects in models of neurodegenerative diseases. It easily crosses the blood-brain barrier and promotes the regeneration of dopamine cells in the central nervous system, leading to functional recovery in rodent models. GPI-1046 has also shown improvements in HIV-associated peripheral nerve injury.