1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepinehydr

• CAT Number: M130629
• CAS Number: 143692-48-2
• Molecular Formula: C19H20N4O3.HCl
• Molecular Weight: 388.85
• Purity: ≥95%
• Synonyms: (S)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4/’,5/’:4,5]benzo[1,2-d][1,2]diazepine-7-carboxamide hydrochloride
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at RT
• InChI: InChI=1S/C19H20N4O3.ClH/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12;/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24);1H
• InChIKey: ASLCSBBDVWPSQT-UHFFFAOYSA-N
• SMILES: CC1N(C(NC)=O)N=C(C2=CC=C(N)C=C2)C3=CC4=C(OCO4)C=C3C1.[H]Cl

GYKI53655 Hydrochloride is a non-competitive AMPA and kainate receptor antagonist. GYKI53655 Hydrochloride exhibits anticonvulsant activity. GYKI53655 Hydrochloride also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.

Reference

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