1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

• CAT Number: M017090
• CAS Number: 117690-79-6
• Molecular Formula: C19H28N4O3
• Molecular Weight: 360.458
• Purity: ≥95%
• Synonyms: 1-(5-ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethanone
• Target: Leukotriene Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• IUPAC Name: 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone
• InChI: InChI=1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
• InChIKey: WCGXJPFHTHQNJL-UHFFFAOYSA-N
• SMILES: CCC1=C(C=C(C(=C1)C(=O)C)O)OCCCCCC(C)(C)C2=NNN=N2

LY 255283 is a a specific leukotriene B4 (LTB4) receptor antagonist. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187.

Reference

1: Uğur M, Melli M. Inhibitory effect of LY 255283 on the synthesis of leukotriene B(4) and thromboxane A(2) in human peripheral blood polymorphonuclear leukocytes and monocytes. Mediators Inflamm. 1993;2(6):407-9. PubMed PMID: 18475555; PubMed Central PMCID: PMC2365434.