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1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
For research use only. Not for therapeutic Use.
LY 255283 is a a specific leukotriene B4 (LTB4) receptor antagonist. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187.
Catalog Number | M017090 |
CAS Number | 117690-79-6 |
Synonyms | 1-(5-ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethanone |
Molecular Formula | C19H28N4O3 |
Purity | ≥95% |
Target | Leukotriene Receptor |
Solubility | Soluble in DMSO > 10 mM |
Storage | Store at +4C |
IUPAC Name | 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone |
InChI | InChI=1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23) |
InChIKey | WCGXJPFHTHQNJL-UHFFFAOYSA-N |
SMILES | CCC1=C(C=C(C(=C1)C(=O)C)O)OCCCCCC(C)(C)C2=NNN=N2 |
Reference | </br>1: Uğur M, Melli M. Inhibitory effect of LY 255283 on the synthesis of leukotriene B(4) and thromboxane A(2) in human peripheral blood polymorphonuclear leukocytes and monocytes. Mediators Inflamm. 1993;2(6):407-9. PubMed PMID: 18475555; PubMed Central PMCID: PMC2365434.</br></br> |