1-(6,7,9,10-Tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepin-8-yl)ethanone

• CAT Number: C000339
• CAS Number: 1213781-59-9
• Molecular Formula: C₁₅H₁₅N₃O
• Molecular Weight: 253.3
• Purity: ≥95%
• Synonyms: N-Acetyl Varenicline; 1-((6R,10S)-9,10-Dihydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8(7H)-yl)ethanone
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Appearance: Light Orange to Orange Solid
• Storage: -20°C, Inert atmosphere

1-(6,7,9,10-Tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepin-8-yl)ethanone (Cat.No:C000339) is related to its parent compound N-Formyl Varenicline , which is a metabolite of Varenicline and metabolite M5. Also, it is derived from Varenicline Tartrate , which is a nicotinic α4β2 acetylcholine receptor partial agonist and used to aid in smoking cessation (1,2,3,4).

Reference

Dow, J., et al.: Drug Metab. Dispos., 22, 738 (1994), Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005)