1-Benzoylnapelline

• CAT Number: T000076
• CAS Number: 198126-85-1
• Molecular Formula: C29H37NO4
• Purity: ≥95%
• Synonyms: 16,17-1alpha-O-Benzoyloxy, 12beta,15beta-dihydroxy, 4beta-methyl, N-ethylnapellane
• Solubility: In butanol; Moderate in chloroform and acetone
• Storage: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

1-Benzoylnapelline(cas 198126-85-1) is an antiarrhythmic.


Diterpenoid Alkaloid<!–C29H37NO4–>, synthesized from Napelline which is extracted from Aconitum karakolicum

It has a potent antiarrhythmic activity on a various models of arrhythmia. It is effective for treatment urgent types of arrhythmia. By its antiarrhythmic activity and therapeutic width, 1-O-benzoylnapelline exceeds known antiarrhythmics such as quinidine, procainamide, ajmaline and lydocaine.

Field of use

Reference

– Jahangirov F.N., Sultanhodzhaev M.N., Tashkhodjaev B., Salimov B.T., Chemistry of Natural Comp. 1997, ? 2, pp. 254-270

– Jahangirov F.N., Shahidoyatova N.H., Chemistry prodnyh Comm. 1998, Spec. Release., pp. 131-135

– Sagdullayev B.T., Abramov A.Y., Gagelgans A.N., Jahangirov F.N., Chemistry of Natural Comp. 1998. Number 4, pp. 523-527

– Jahangirov F.N., Badalyants K., Shahidoyatova N.H., CIL spec. issue 1999

– Dzhakhangirov F.N., Sultankhodzhaev M.N., Tashkhodjaev B., Salimov B.T., Chemistry of Natural Comp. 1997, ? 2, pp. 254-270

– Shahidoyatova N.H., Dzhakhangirov F.N., Sultankhodzhaev M.N., Chem-Pharm jornal 2001, ?5, p.31(Russ)