1-(Diaminomethylene)-3-b-D-ribofuranosyl-urea Picrate

• CAT Number: C000148
• CAS Number: 4336-46-3
• Molecular Formula: C₇H₁₄N₄O₅ • ( C₆H₃N₃O₇)
• Purity: ≥95%
• Synonyms: 1-Amidino-3-β-D-ribofuranosyl-urea Monopicrate; NSC 232826; Azacitidine USP Related Compound C
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Appearance: Pale Yellow to Yellow Solid
• Storage: -20°C, Hygroscopic

1-(Diaminomethylene)-3-b-D-ribofuranosyl-urea Picrate(CAT: C000148) holds significance in the field of pharmaceutical chemistry, particularly in the context of treating myelodysplastic syndromes (MDS). It is a related compound of Azacitidine, a DNA methyltransferase (DNMT) inhibitor utilized in the treatment of MDS. Azacitidine’s mechanism of action involves its ability to inhibit DNMT, leading to changes in DNA methylation patterns and gene expression.

Reference

Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)