For research use only. Not for therapeutic Use.
1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016564 |
| CAS Number | 1835759-69-7 |
| Synonyms | 2-[2-[2-(2-isothiocyanatoethoxy)ethoxy]ethoxy]ethanol |
| Molecular Formula | C9H17NO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C9H17NO4S/c11-2-4-13-6-8-14-7-5-12-3-1-10-9-15/h11H,1-8H2 |
| InChIKey | ZFBITNPIULLZRY-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCO)N=C=S |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
