1-Methyladenine

• CAT Number: I046265
• CAS Number: 5142-22-3
• Molecular Formula: C6H7N5
• Molecular Weight: 149.15
• Purity: ≥95%
• Synonyms: 1-methyl-7H-purin-6-imine
• InChI: InChI=1S/C6H7N5/c1-11-3-10-6-4(5(11)7)8-2-9-6/h2-3,7H,1H3,(H,8,9)
• InChIKey: SATCOUWSAZBIJO-UHFFFAOYSA-N
• SMILES: CN1C=NC2=C(C1=N)NC=N2

1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

Reference

[1]. Falnes PØ, et al. Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Res. 2004 Dec 1;32(21):6260-7. Print 2004.
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[2]. Yang H, et al. Effect of 1-methyladenine on double-helical DNA structures. FEBS Lett. 2008 May 14;582(11):1629-33.
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