1-Methylnicotinamide Chloride

• CAT Number: R024825
• CAS Number: 1005-24-9
• Molecular Formula: C7H9ClN2O
• Molecular Weight: 172.612
• Purity: ≥95%
• Synonyms: 3-(Aminocarbonyl)-1-methylpyridinium Chloride; 3-Carbamoyl-1-methylpyridinium Chloride; 1-Methyl-3-carbamoylpyridinium Chloride; N-Methyl-3-carboxamidepyridinium Chloride; N-Methylnicotinamide Chloride; N1-Methylnicotinamide Chloride; Nicotinamide Me
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: 1-methylpyridin-1-ium-3-carboxamide;chloride
• InChI: InChI=1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
• InChIKey: BWVDQVQUNNBTLK-UHFFFAOYSA-N
• SMILES: C[N+]1=CC=CC(=C1)C(=O)N.[Cl-]

Nicotinamide is a precursor of NAD (Item No. 16077) and NADP (Item No. 10004675), which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; Item No. 15138). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.