1-Naphthohydroxamic acid

• CAT Number: I016974
• CAS Number: 6953-61-3
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19
• Purity: ≥95%
• Target: Epigenetics
• Storage: 2-8°C
• IUPAC Name: N-hydroxynaphthalene-1-carboxamide
• InChI: InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
• InChIKey: JRZGPWOEHDOVMC-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=CC=C2C(=O)NO

1-Naphthohydroxamic acid (Cat No.:I016974) is a potent and selective HDAC8 inhibitor with IC50 of 14μM. The selectivity of 1-Naphthohydroxamic acid for HDAC8 is higher than class I HDAC1 and II  class HDAC6 (IC50>100μM). 1-Naphthohydroxamic acid does not increase overall histone H4 acetylation, nor does it decrease total intracellular HDAC activity. 1-Naphthohydroxamic acid induces tubulin acetylation.

Reference

[1]. Krennhrubec K, et al. Design and evaluation of ‘Linkerless’ hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8.[2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9.