1-Naphthyl PP1

• CAT Number: I002694
• CAS Number: 221243-82-9
• Molecular Formula: C19H19N5
• Molecular Weight: 317.40
• Purity: ≥95%
• Synonyms: 1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine
• Target: Apoptosis
• Solubility: DMSO: ≤ 14.25 mg/mL
• Storage: Store at +4C
• IC50: 1.0 uM (v-Src); 0.6 uM (c-Fyn); 18 uM (c-Abl) [1]
• InChI: 1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
• InChIKey: XSHQBIXMLULFEV-UHFFFAOYSA-N
• SMILES: CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N

1-Naphthyl PP1 (Cat No.: I002694) is a selective inhibitor of Src-family tyrosine kinases, commonly used in chemical genetics and signal transduction research. It is particularly valuable for studying analog-sensitive kinase mutants, allowing precise temporal control of kinase activity in cells. By binding to engineered kinase variants with modified ATP-binding pockets, 1-Naphthyl PP1 enables selective inhibition without affecting wild-type kinases. This compound aids in dissecting kinase functions in pathways related to cell growth, differentiation, and cancer, making it a powerful tool in functional proteomics.

Reference

[1]. Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401.
[2]. Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601.