1-Oleoyl-2-acetyl-sn-glycerol

• CAT Number: R000349
• CAS Number: 86390-77-4
• Molecular Formula: C23H42O5
• Molecular Weight: 398.584
• Purity: ≥95%
• Synonyms: 1-Oleoyl-2-acetyl-glycerol; 1-Oleoyl-2-acetylglycerol; (9Z)-9-Octadecenoic Acid 2-(Acetyloxy)-3-hydroxypropyl Ester; OAG
• Target: TGF-beta/Smad
• Storage: -80°C
• IUPAC Name: [(2S)-2-acetyloxy-3-hydroxypropyl] (Z)-octadec-9-enoate
• InChI: InChI=1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
• InChIKey: PWTCCMJTPHCGMS-YRBAHSOBSA-N
• SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(CO)OC(=O)C

OAG is a cell-<wbr></wbr>permeable analog of the PKC-<wbr></wbr>activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. OAG is metabolized to its corresponding phosphatidic acid (1-<wbr></wbr>oleoyl-<wbr></wbr>2-<wbr></wbr>acetyl-<wbr></wbr>3-<wbr></wbr>phosphoglycerol), most likely through the action of a diglycerol kinase.