1-Stearoyl-2-Arachidonoyl PC

• CAT Number: R029604
• CAS Number: 35418-59-8
• Molecular Formula: C46H84NO8P
• Molecular Weight: 810.1
• Purity: ≥95%
• Synonyms: SAPC;1-Stearoyl-2-Arachidonoyl-Phosphatidylcholine
• Target: Endogenous Metabolite
• Storage: -20°C
• InChI: InChI=1S/C46H84NO8P/c1-6-8-10-12-14-16-18-20-22-23-25-27-29-31-33-35-37-39-46(49)55-44(43-54-56(50,51)53-41-40-47(3,4)5)42-52-45(48)38-36-34-32-30-28-26-24-21-19-17-15-13-11-9-7-2/h14,16,20,22,25,27,31,33,44H,6-13,15,17-19,21,23-24,26,28-30,32,34-43H
• InChIKey: PSVRFUPOQYJOOZ-QNPWAGBNSA-N
• SMILES: O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCC/C=CC/C=CC/C=CC/C=CCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O

Phosphatidylcholine species are a common class of phospholipids that comprise the mammalian cell membrane. 1-<wbr></wbr>Stearoyl-<wbr></wbr>2-<wbr></wbr>arachidonoyl phosphatidylcholine (SAPC) is an important source of activation-<wbr></wbr>induced arachidonate released as a substrate for cyclooxygenase (COX-<wbr></wbr>2) mediated signaling. It is the preferred substrate for the 85 kDa cytosolic phospholipase, which translocates to endoplasmic and nuclear membranes in response to the activation-<wbr></wbr>induced rise in intracellular calcium. The arachidonate thus liberated can be utilized by either COX or lipoxygenase enzymes for the elaboration of further eicosanoid mediators.

Reference

1.Bittova, L.,Sumandea, M., and Cho, W. A structure-function study of the C2 domain of cytosolic phospholipase A2. Identification of essential calcium ligands and hydrophobic membrane binding residues. The Journal of Biological Chemisty 274, 9665-9672 (19