For research use only. Not for therapeutic Use.
Phosphatidylcholine species are a common class of phospholipids that comprise the mammalian cell membrane. 1-<wbr></wbr>Stearoyl-<wbr></wbr>2-<wbr></wbr>arachidonoyl phosphatidylcholine (SAPC) is an important source of activation-<wbr></wbr>induced arachidonate released as a substrate for cyclooxygenase (COX-<wbr></wbr>2) mediated signaling. It is the preferred substrate for the 85 kDa cytosolic phospholipase, which translocates to endoplasmic and nuclear membranes in response to the activation-<wbr></wbr>induced rise in intracellular calcium. The arachidonate thus liberated can be utilized by either COX or lipoxygenase enzymes for the elaboration of further eicosanoid mediators.
| CAS Number | 35418-59-8 |
| Synonyms | SAPC;1-Stearoyl-2-Arachidonoyl-Phosphatidylcholine |
| Molecular Formula | C46H84NO8P |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -20°C |
| InChI | InChI=1S/C46H84NO8P/c1-6-8-10-12-14-16-18-20-22-23-25-27-29-31-33-35-37-39-46(49)55-44(43-54-56(50,51)53-41-40-47(3,4)5)42-52-45(48)38-36-34-32-30-28-26-24-21-19-17-15-13-11-9-7-2/h14,16,20,22,25,27,31,33,44H,6-13,15,17-19,21,23-24,26,28-30,32,34-43H |
| InChIKey | PSVRFUPOQYJOOZ-QNPWAGBNSA-N |
| SMILES | O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCC/C=CC/C=CC/C=CC/C=CCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O |
| Reference | 1.Bittova, L.,Sumandea, M., and Cho, W. A structure-function study of the C2 domain of cytosolic phospholipase A2. Identification of essential calcium ligands and hydrophobic membrane binding residues. The Journal of Biological Chemisty 274, 9665-9672 (19 |
