10-Deacetyl-7-xylosyl paclitaxel

• CAT Number: I005402
• CAS Number: 90332-63-1
• Molecular Formula: C50H57NO17
• Molecular Weight: 943.98
• Purity: ≥95%
• Target: Cytoskeleton
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,12-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
• InChI: InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1
• InChIKey: ORKLEZFXASNLFJ-DYLQFHMVSA-N
• SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)C)O

10-Deacetyl-7-xylosyl paclitaxel(Cat No.:I005402)is a modified form of paclitaxel, a widely used anticancer drug derived from the Pacific yew tree. This derivative has been chemically modified to improve its pharmacological properties, particularly its water solubility. By attaching a xylosyl group to the 7-position of the paclitaxel molecule and removing the acetyl group at the 10-position, 10-Deacetyl-7-xylosyl paclitaxel exhibits enhanced solubility in water compared to paclitaxel. This improved water solubility can potentially facilitate its formulation and administration in clinical settings, leading to better drug delivery and therapeutic efficacy. Further studies are being conducted to explore its potential applications in cancer treatment.

Reference

[1]. Jiang S, et al. Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel. Int J Oncol. 2008 Jul;33(1):103-11.