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28459-40-7-10-Formyldihydrofolate 10-Formyldihydrofolate

10-Formyldihydrofolate

For research use only. Not for therapeutic Use.

  • CAT Number: I016405
  • CAS Number: 28459-40-7
  • Molecular Formula: C20H21N7O7
  • Molecular Weight: 471.43
  • Purity: 98%
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Related Small Molecules: 7ß,27-Dihydroxycholesterol     Castanospermine     Benzyl L-leucyl-L-phenylalaninate TFA    

10-Formyldihydrofolate is a Methotrexate metabolite; inhibits thymidylate synthetase and glycinamide ribotide transformylase.


Catalog Number I016405
CAS Number 28459-40-7
Synonyms

10-Formyldihydrofolate;

Molecular Formula C20H21N7O7
Purity 98%
Target Endogenous Metabolite
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (4-(N-((2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl)formamido)benzoyl)-L-glutamic acid
InChI InChI=1S/C20H21N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,13H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t13-/m0/s1
InChIKey UXFQDXABPXWSTK-ZDUSSCGKSA-N
SMILES O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(NC(N)=NC3=O)NC2)C=O)C=C1)=O
Reference

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2: Naz N, Jimenez AR, Sanjuan-Vilaplana A, Gurney M, Miyan J. Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10-formyltetrahydrofolate dehydrogenase. J Neurochem. 2016 Aug;138(4):610-23. doi: 10.1111/jnc.13686. Epub 2016 Jul 25. PubMed PMID: 27294849.
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