For research use only. Not for therapeutic Use.
11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland. It is a metabolite of progesterone (Item No. <span class=/itemid/>15876</span>) and precursor to aldosterone (Item No. <span class=/itemid/>15273</span>) and corticosterone (Item No. <span class=/itemid/>16063</span>). DOC is metabolized to the neuroactive compound (3α,5α)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABA<sub>A</sub> receptors and produces effects similar to barbiturates in rats. Injections of naloxone (Item Nos. <span class=/itemid/>15594</span> | <span class=/itemid/>ISO60191</span>) and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys. DOC levels are increased 3.4-fold in obese and diabetic mice.
| Catalog Number | R053089 |
| CAS Number | 64-85-7 |
| Synonyms | 21-Hydroxypregn-4-ene-3,20-dione; 11-Deoxycorticosterone; 11-Dehydroxy-?corticosterone; 11-Desoxycorticosterone; 21-Hydroxy-3,20-dioxopregn?-4-ene; 21-Hydroxy-4-pregnane-3,20-dione; 21-Hydroxyprogesterone; Cortexone; DOC; Deoxycortone; Desoxycorticos |
| Molecular Formula | C21H30O3 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Storage | -20°C |
| IUPAC Name | (8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| InChI | InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1 |
| InChIKey | ZESRJSPZRDMNHY-YFWFAHHUSA-N |
| SMILES | CC12CCC3C(C1CCC2C(=O)CO)CCC4=CC(=O)CCC34C |
