11-Keto fusidic acid

• CAT Number: R012870
• CAS Number: 16711-91-4
• Molecular Formula: C31H46O6
• Molecular Weight: 514.69
• Purity: ≥95%
• Synonyms: (2Z)-2-[(3R,4S,5S,8S,9S,10S,13R,14S,16S)-16-acetyloxy-3-hydroxy-4,8,10,14-tetramethyl-11-oxo-1,2,3,4,5,6,7,9,12,13,15,16-dodecahydrocyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
• InChI: InChI=1S/C31H46O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-23,25,27,33H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,25-,27-,29-,30-,31-/m0/s1
• InChIKey: RLYFYROONDDGHK-DMLPZSAWSA-N
• SMILES: CC1C2CCC3(C(C2(CCC1O)C)C(=O)CC4C3(CC(C4=C(CCC=C(C)C)C(=O)O)OC(=O)C)C)C

11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.

Reference

[1]. Cheng X, et al. Fusidane-Type Antibiotics from the Marine-Derived Fungus Simplicillium sp. SCSIO 41513. J Nat Prod. 2021 Nov 10.
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