11-Keto Loteprednol Etabonate

• CAT Number: C000802
• CAS Number: 207670-54-0
• Molecular Formula: C₂₄H₂₉ClO₇
• Molecular Weight: 464.94
• Purity: ≥95%
• Synonyms: (8S,9S,10R,13S,14S,17R)-Chloromethyl 17-((Ethoxycarbonyl)oxy)-10,13-dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• Appearance: White to Pale Yellow Solid
• Storage: -20°C, Hygroscopic
• IUPAC Name: chloromethyl 17-ethoxycarbonyloxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylate
• InChI: InChI=1S/C24H29ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-17,19H,4-6,8,10,12-13H2,1-3H3
• InChIKey: UJMSHOQZQCLVEP-UHFFFAOYSA-N
• SMILES: CCOC(=O)OC1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)C=CC34C)C)C(=O)OCCl

11-Keto loteprednol etabonate (Cat No.:C000802) is a derivative of loteprednol etabonate, a corticosteroid used in ophthalmic treatments for inflammatory eye conditions. With a keto group at position 11, this compound likely exhibits altered pharmacological properties compared to its parent molecule. Researchers may investigate its effects on ocular inflammation and related pathways, potentially contributing to the development of more targeted and effective therapies for eye disorders. Its modification could influence its binding affinity to corticosteroid receptors, impacting its anti-inflammatory and immunosuppressive activities, crucial for managing conditions like allergic conjunctivitis and post-operative inflammation.

Reference

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