1,1,1-Trifluoroethyl-PEG2-azide

• CAT Number: I015774
• CAS Number: 1835759-68-6
• Molecular Formula: C6H10F3N3O2
• Molecular Weight: 213.16
• Purity: ≥95%
• Synonyms: 2-[2-(2-azidoethoxy)ethoxy]-1,1,1-trifluoroethane
• InChI: InChI=1S/C6H10F3N3O2/c7-6(8,9)5-14-4-3-13-2-1-11-12-10/h1-5H2
• InChIKey: HSRLFQUDMWNYCB-UHFFFAOYSA-N
• SMILES: C(COCCOCC(F)(F)F)N=[N+]=[N-]

1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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