1,1,1-Trifluoroethyl-PEG2-propargyl

• CAT Number: I015740
• CAS Number: 1835759-73-3
• Molecular Formula: C9H13F3O3
• Molecular Weight: 226.19
• Purity: ≥95%
• Synonyms: 3-[2-[2-(2,2,2-trifluoroethoxy)ethoxy]ethoxy]prop-1-yne
• InChI: InChI=1S/C9H13F3O3/c1-2-3-13-4-5-14-6-7-15-8-9(10,11)12/h1H,3-8H2
• InChIKey: HILROVSZUWJRKP-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCC(F)(F)F

1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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