For research use only. Not for therapeutic Use.
1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519)[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].
Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[3].
| Catalog Number | I045309 |
| CAS Number | 3475-39-6 |
| Synonyms | 1,1,3-tribromopropan-2-one |
| Molecular Formula | C3H3Br3O |
| Purity | ≥95% |
| InChI | InChI=1S/C3H3Br3O/c4-1-2(7)3(5)6/h3H,1H2 |
| InChIKey | FNYCCOFOQIUTIM-UHFFFAOYSA-N |
| SMILES | C(C(=O)C(Br)Br)Br |
| Reference | [1]. Balwant Singh, et al. Process for the preparation of high purity methotrexate and derivatives thereof. Patent US4374987A 87A [2]. [2].Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92 [3]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund’s complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550. |
