For research use only. Not for therapeutic Use.
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].
116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1].
116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1].
| Catalog Number | I012493 |
| CAS Number | 831217-43-7 |
| Synonyms | 6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid |
| Molecular Formula | C31H32N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H32N2O5/c1-22-28(30(36)38-21-23-11-5-2-6-12-23)29(32-31(37)33(22)20-10-4-9-15-27(34)35)26-18-16-25(17-19-26)24-13-7-3-8-14-24/h2-3,5-8,11-14,16-19,29H,4,9-10,15,20-21H2,1H3,(H,32,37)(H,34,35) |
| InChIKey | GHFQWLNXJMUCGC-UHFFFAOYSA-N |
| SMILES | CC1=C(C(NC(=O)N1CCCCCC(=O)O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC=C4 |
| Reference | [1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80. [2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831. |
