(11b,16a)-9-Chloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-21-[(methylsulfonyl)oxy]-pregna-1,4-diene-3,20-dione (Mometasone Impurity R)

• CAT Number: C001097
• CAS Number: 1370190-08-1
• Molecular Formula: C₂₈H₃₃ClO₉S
• Molecular Weight: 581.07
• Purity: ≥95%
• Synonyms: 9-Chloro-11β-hydroxy-16α-methyl-21-[(methylsulfonyl)oxy]-3,20-dioxopregna-1,4-dien-17-yl Furan-2-carboxylate
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Storage: -20°C, Inert atmosphere
• IUPAC Name: [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-17-(2-methylsulfonyloxyacetyl)-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
• InChI: InChI=1S/C28H33ClO9S/c1-16-12-20-19-8-7-17-13-18(30)9-10-25(17,2)27(19,29)22(31)14-26(20,3)28(16,23(32)15-37-39(4,34)35)38-24(33)21-6-5-11-36-21/h5-6,9-11,13,16,19-20,22,31H,7-8,12,14-15H2,1-4H3/t16-,19+,20+,22+,25+,26+,27+,28+/m1/s1
• InChIKey: AVTGVLGPYCPSRO-OKCRLJKSSA-N
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COS(=O)(=O)C)OC(=O)C5=CC=CO5)C)O)Cl)C

(11b,16a)-9-Chloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-21-[(methylsulfonyl)oxy]-pregna-1,4-diene-3,20-dione（Cat No.:C001097）, commonly known as Mometasone Impurity R, is a complex derivative of the corticosteroid mometasone. This compound features multiple functional groups, including a chloro, furanylcarbonyl, hydroxy, methyl, and methylsulfonyl group, enhancing its specificity and reactivity. This impurity is of particular interest in the quality control of pharmaceutical formulations containing mometasone, used primarily for its anti-inflammatory and immunosuppressive properties. Analyzing and understanding this impurity is crucial for ensuring the safety and efficacy of mometasone-based medications.