1,2-Bis(2-iodoethoxy)ethane

• CAT Number: I016890
• CAS Number: 36839-55-1
• Molecular Formula: C₆H₁₂I₂O₂
• Molecular Weight: 369.97
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: 2–8 °C
• IUPAC Name: 1,2-bis(2-iodoethoxy)ethane
• InChI: InChI=1S/C6H12I2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2
• InChIKey: BCAGFJXMCZSAHD-UHFFFAOYSA-N
• SMILES: C(COCCI)OCCI

1,2-Bis(2-iodoethoxy)ethane（Cat No.:I016890） is a polyethylene glycol (PEG)-based linker commonly used in the synthesis of proteolysis-targeting chimera (PROTAC) molecules. It has been utilized in the synthesis of two specific compounds: MT802 (HY-122562) and SJF620 (HY-133137). MT802 and SJF620 are highly potent PROTAC BTK (Bruton’s tyrosine kinase) degraders. MT802 exhibits a DC50 (dose required for 50% degradation) of 1 nM, while SJF620 has a DC50 of 7.9 nM. These compounds have demonstrated strong activity in the targeted degradation of BTK protein, making them promising candidates for therapeutic applications related to BTK-associated diseases.

Reference

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.